Arousal mediates relations among medial paw preference, lateral paw preference, and spatial preference in the mouse.

Rodents exhibit two well-documented behavioural lateralities: spatial preference and paw preference. Waters and Denenberg [36] have identified two seemingly independent factors of paw preference: medial and lateral paw preference. In the present work, the relations among spatial preference (SP), medial paw preference (MPP), and lateral paw preference (LPP) during states of high and low arousal were examined. These preferences were measured in terms of direction, which describes the side of the preference regardless of strength, and degree, which describes the strength of the preference regardless of direction. A strong positive correlation between LPP and SP was found during periods of high, but not low, arousal. A negative correlation between the degree components of LPP and MPP was found during the low, but not high, arousal periods.